منابع مشابه
Immunopathogenesis of atherosclerosis.
Recent clinical studies indicate that the number of microbial infections (the "pathogen burden") critically determines the development and progression of atherosclerotic disease. Viruses or bacteria with a specific tropism for cells of the vascular wall may contribute to the initial vascular injury via direct cytopathic effects or via the induction of genuine autoimmune responses. Immunopatholo...
متن کاملImmunopathogenesis of atherosclerosis.
To the Editor: We read with great interest the article on acceleration of atherosclerosis by nonspecific stimulation of the immune system. Lehr and colleagues1 showed data supporting the concept that atherosclerosis has an immunopathological component, making improbable that a single infectious agent should assume particular importance in its initiation or progression. We tested this hypothesis...
متن کاملImmunopathogenesis of atherosclerosis: endotoxin accelerates atherosclerosis in rabbits on hypercholesterolemic diet.
BACKGROUND On the basis of our concept that atherosclerosis has an immunopathological background, we tested whether activation of the innate immune system influences its progression. METHODS AND RESULTS Hypercholesterolemic (0.5% wt/wt diet) rabbits received either repeated intravenous injections of endotoxin (Escherichia coli lipopolysaccharide 1.25 to 2.5 microg, once per week) or a self-li...
متن کاملImmunopathogenesis of Sarcoidosis
Sarcoidosis is a multisystemic disease in which inflammatory cells gather and form nodules known as non caseating epithelioid granulomas. The most commonly affected organs are the lungs, the eyes and the skin whereas all the organs can be potentially affected. The disease can develop when genetically susceptible individuals are exposed to environmental agents with antigenic properties. These ca...
متن کاملImmunopathogenesis of psoriasis.
Psoriasis is a common inflammatory disease affecting 1% of the Brazilian population. Th17 and Th1cells are involved with the immunopathogenisis of psoriasis. In this article it is discussed the interaction between the innate immunity (especially dendritic cells and keratinocytes) and adaptive immunity (T lymphocytes) in the pathogenesis of psoriasis.
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ژورنال
عنوان ژورنال: Circulation
سال: 2002
ISSN: 0009-7322,1524-4539
DOI: 10.1161/circ.105.10.e64